Quit smoking, help find cures, and sometimes even get paid–that’s the power of clinical studies. By enrolling in such efforts, smokers not only gain access to cutting-edge therapies and interventions but may also play a vital role in improving cessation strategies. By learning about upcoming opportunities, you can find out if a clinical trial is right for you.
What Are Smoking Cessation Clinical Trials?
Smoking cessation clinical trials are research studies designed to test new ways to help individuals quit smoking. These trials may evaluate medications, behavioral therapy, digital tools, or a combination of treatments to see what works best. Participants are typically monitored closely and may receive treatments not yet available to the public.
Many trials also explore how different groups respond to cessation methods—such as veterans, pregnant women, or individuals with PTSD. The goal is to identify effective, personalized solutions for quitting smoking and to minimize relapse. If you’re a smoker who’s struggled with quitting through traditional methods, participating in a clinical trial could introduce you to innovative techniques that make a real difference.
Why Participate? Benefits and Compensation
Participants in clinical trials often receive no-fee access to treatment, regular health monitoring, and the satisfaction of helping advance science. In many cases, volunteers are also compensated for their time and effort. Compensation can include reimbursement for transportation, meals, lost wages, and general participation, depending on the trial’s scope and duration.
While pay is not always guaranteed, most reputable trials offer some form of financial incentive, especially if multiple visits or procedures are involved. Beyond money, the biggest benefit for many is having expert support to quit smoking–something that may not be as accessible through standard care. Plus, you’ll be contributing to research that can save lives, including your own.
Where To Find Clinical Trials for Smokers
If you’re interested in joining a smoking cessation study, several trusted sources can help you find one that matches your needs. The official government database, ClinicalTrials.gov, lists thousands of current studies. You can search by location, condition, and eligibility criteria. Another reliable source is the Mayo Clinic, which regularly conducts research on nicotine dependence.
Other helpful platforms include FindPaidClinicalTrials.com and university research hospitals. Some trials are location-based, while others offer remote participation. Be sure to read the eligibility requirements carefully and contact the study coordinator for any questions. Many sites allow you to sign up for alerts about new trials in your area.
Clinical Trials to Consider
Here are some currently enrolling studies that smokers may be eligible for:
- The Effect of Emotional Freedom Techniques (EFT): For smokers who have failed traditional cessation programs, this UK-based study explores EFT as a potential intervention. Open to all genders and ages 12–99.
- CPT-SMART for Veterans with PTSD: Focused on veterans, this trial combines smoking cessation with PTSD therapy. Located in Durham, NC, and open to adults up to age 80.
- Hormonal Intervention for Postpartum Smokers: This University of Minnesota study tests hormone therapy to prevent postpartum relapse and improve infant health outcomes.
- Facebook-Based Intervention for Alaska Native Smokers: Mayo Clinic is piloting a culturally tailored program delivered via social media to promote cessation among Alaska Native populations.
- High-Dose Nicotine Patch Study: Aimed at users of smokeless tobacco, this Mayo Clinic study evaluates whether stronger nicotine patches can boost long-term quitting success.
- Decision Aid for Smokers Undergoing Surgery: Another Mayo Clinic study, this one focuses on developing tools to help smokers make informed choices before elective surgeries.
These examples showcase the diversity of approaches being explored and the wide range of people who can qualify.
How To Decide If a Trial Is Right for You
Joining a clinical trial is a personal decision that should be made after considering both your health needs and comfort level. Read the study details carefully and talk with the research coordinator about what’s involved. Understand that while compensation is helpful, it should never be your main reason for participating.
Further, think about your goals. Do you want to quit smoking, try new treatments, or contribute to research? Are you okay with frequent visits or medical procedures? Also, consider whether the trial offers the kind of support or access you need. When chosen wisely, participating in a trial can be both a healing and empowering experience.
Take the First Step Toward Change
Clinical trials for smokers are more than just experiments, they’re opportunities. Opportunities to access new treatments, receive personalized support, and take control of your health.
With a growing number of programs now enrolling, there’s likely one that fits your needs. Whether your goal is to quit for good or contribute to science, the time to explore your options is now.